Understanding the Importance of Sequencing Technologies in P…

BioSc 119 Short paper assignment #1 Understanding the Importance of Sequencing

Technologies in Pathogen Detection:

To explore the pivotal role of genomic technologies, particularly sequencing techniques, in

understanding and detecting emerging pathogens and viruses. As future microbiologists or heath

related fields professional, it’s essential to recognize that while traditional methods (like staining

and isolation) remain foundational, modern tools offer quick, non-cultivation based insights into

pathogens. Utilize the article provided to understand the impact and advancements of sequencing

technologies. You may also consult other reliable scientific sources for further information.

Choose a focus:

Pathogen Diversity and Evolution: Explore how high-throughput sequencing has shed light on

pathogen diversification, adaptation, and the origins of specific phenotypes. How has sequencing

data provided a high-resolution view of these processes?

Antimicrobial Resistance (AMR): Delve into how sequencing techniques have informed our

understanding of AMR. How do pathogens develop resistance, and how has genomic data aided

in detecting such resistance?

Infectious Disease Forecasting: Study the current challenges in integrating pathogen diversity

into forecasting models. Why is it crucial for models to incorporate this diversity, and how might

future forecasting benefit from sequencing technologies?

Report Outline:

Introduction: Brief overview of traditional microbiology techniques.

Introduction to sequencing technologies and their growing importance in the field of

microbiology.

Historical Context: Briefly describe the evolution of pathogen detection techniques.

Highlight the transition from cultivation-based techniques to sequencing.

Deep Dive (based on your chosen focus):

For Pathogen Diversity and Evolution:

Discuss the high-resolution view that sequencing offers into pathogen diversification and

adaptation.

Explore examples like the diversification of viruses or the emergence of AMR strains

post-antibiotic introduction.

For Antimicrobial Resistance (AMR):

Explain the phenomenon of AMR and its global impact.

Delve into how sequencing has enabled the detection of resistance alleles or genes.

Use examples like the resistance patterns in M. tuberculosis, E. coli, or other relevant

pathogens.

For Infectious Disease Forecasting:

Describe the traditional models used for forecasting infectious diseases. Discuss the

challenges and limitations of these models.

Highlight the need for integrating sequencing data and pathogen diversity into forecasting

models.

Benefits and Limitations of Sequencing:

Discuss the advantages sequencing technologies offer over traditional methods.

Touch upon any limitations or challenges that still exist in the realm of sequencing for

pathogen detection.

Conclusion:

Summarize the transformative role of sequencing technologies in microbiology. Reflect on its

potential in shaping the future of pathogen detection, understanding, and intervention.

References:

Cite all sources you’ve used in APA format.

PICK WHICH TOPIC IN THE INSTRUCTIONS YOU WOULD LIKE TO WRITE ABOUT