RNA

Overview

You were introduced to non-coding RNAs that can be used to regulate the expression of other genes. In particular, you reviewed the biogenesis of RNAi (siRNA and miRNA) in the lecture and covered the functional significance of RNAi in vivo based on the three assigned articles. This exercise will focus on your understanding from those articles.

Instructions

Compose a paragraph-style response for the two essay prompts listed below. The assignment must reflect your own understanding of the course material.

1. Based on Origins and Mechanisms of miRNAs and siRNAs, describe 1 of the 5 modes by which miRNAs can inhibit translation.

2. Based on the regulation of Dnmt3a and Dnmt1, state how the following conditions might alter the levels of these proteins.

a) The loss of Dicer activity (i.e., cells become Dicer-/-)

b) Overexpression of Rbl2

c) Loss of expression from the miR-290 cluster

Be sure to label each answer by its number. Ensure that all answers to the questions are detailed in sentence format in a manner that explains your understanding.

use the following sources:

Must be 100% AI and plagiarism free, and put citations in AMA format