Question for the expert: Ive found that only SURPASS-CVOT and SURPASS-4 report the complete MACE endpoints, while the other SURPASS trials (17) do not consistently include all components. As a meta-analysis expert, what should I do if I currently have only two trials with complete MACE data? Can I still include the other SURPASS trials?
I also came across a meta-analysis that included one phase 2 trial, five international phase 3 trials, and one regional phase 3 trial in Japan, as long as each trial had at least one MACE-4 event. That approach fits their objective, but my goal is stricter: I want to include only studies that report all MACE-3 (or MACE-4) components. What is the best approach in my case?
RCTS with complete mace endpoints:
Requirements: full
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