PET radiopharmaceuticals

I want a literature review on How have PET radiopharmaceuticals evolved alongside advances in molecular and metabolic understanding of disease?

Structure of the Paper

Introduction

Brief definition of PET

Importance of tracer specificity

Clear thesis statement:

The evolution of PET radiopharmaceuticals parallels advancements in molecular understanding of disease biology

2? Phase 1 Metabolic Imaging

Example: FDG

Biological concept: increased glycolysis

Strength: high sensitivity

Limitation: poor specificity

Transition: need for more targeted imaging

3? Phase 2 Receptor-Based Targeting

Example: receptor-targeted tracers

Biological concept: receptor overexpression

Strength: improved specificity

Limitation: heterogeneous expression

Transition: need to image intracellular processes

4? Phase 3 Enzyme / Pathway Imagin

Example: enzyme-targeted tracers

Biological concept: DNA synthesis or proliferation

Strength: reflects specific cellular activity

Limitation: variable uptake

Transition: disease involves more than just tumor cells

5? Phase 4 Microenvironment & Advanced Targeting

Example: microenvironment-targeted tracers

Biological concept: stromal and extracellular components

Strength: higher tumor-to-background ratios

Direction: precision molecular imaging

What to Include in Each Section

For every phase, include only five elements:

1.Biological discovery

2.Target type

3.Tracer mechanism

4.Strengths

5.Limitations + transition to next phase

Requirements: 15

Comments