Can anyone help me with this, I use ChatGpt it give wrong information and I just need and help some on to verify my references
whith APA citation
my original that I got flagged for In Hirschsprung disease, the nerve cells do not form correctly during pregnancy because the neural crest cells fail to migrate to the bowel. Since that part of the bowel cannot relax, stool gets stuck, which causes blockage. This can lead to constipation and a swollen belly, and the bowel above the blocked area becomes enlarged. On a cellular level, the bowel is missing the normal signals like nitric oxide that help smooth muscle relax, so peristalsis does not work
normally.
Hirschsprung disease is more common in male infants and is sometimes linked to genetic causes. Some cases are related to gene mutations like RET, which affect nerve development in the intestines.
The I did some research Rewritten Paragraph (APA with Sources)
Hirschsprung disease is a congenital disorder caused by failure of neural crestderived ganglion cells to migrate into the distal intestine during fetal development, resulting in an aganglionic segment of bowel (American Academy of Family Physicians, 2006). The aganglionic bowel cannot relax normally, leading to functional obstruction and proximal dilation (American Academy of Family Physicians, 2006). Loss of inhibitory nitrergic (nitric oxideproducing) innervation likely contributes to impaired smooth muscle relaxation and abnormal peristalsis in the affected segment (Larsson et al., 1995; Bealer et al., 1994). Definitive diagnosis is confirmed by rectal biopsy demonstrating absence of ganglion cells (Monforte et al., 2025; Merck Manual, 2025). Hirschsprung disease is more common in males, and RET gene mutations are a major known genetic contributor to abnormal enteric nervous system development (StatPearls, 2025; MedlinePlus Genetics, 2025).
Full References (APA format)
Clinical overview / pathophysiology
American Academy of Family Physicians. (2006). Hirschsprung disease. American Family Physician, 74(8), 13191322.
Nitrergic innervation & smooth muscle relaxation
Bealer, S. L., Breese, E. L., & Wang, Q. (1994). Nitrergic nerve function in Hirschsprung disease. Journal of Pediatric Surgery, 29(4), 426431.
Larsson, H. P., Ekblad, E., Jodal, M., & Sundler, F. (1995). Loss of nitrergic inhibitory innervation in aganglionic bowel of Hirschsprung disease. Journal of Pediatric Surgery, 30(7), 963969.
Biopsy & surgical confirmation
Monforte, H. L., Wilsey, M., & Gonzalez, R. (2025). Surgical pathology of Hirschsprung disease (HSCR). World Journal of Pediatric Surgery.
Epidemiology / male predominance
StatPearls. (2025). Hirschsprung Disease. In StatPearls [Internet].
https://www.ncbi.nlm.nih.gov/books/NBK562142/
Genetics / RET mutations
MedlinePlus Genetics. (2025). Hirschsprung disease.
https://medlineplus.gov/genetics/condition/hirschsprung-disease/
Additional clinical reference
Merck Manual. (2025). Hirschsprung Disease.
https://www.merckmanuals.com/professional/pediatrics/congenital-gastrointestinal-anomalies/hirschsprung-disease

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