circRNA and their role in development of salivary glands

Length and format

• 2 pages: main text
• 1 page: references
• No subheadings (one continuous narrative)
• Start directly with the topic (no long introductory lead-in)
• Use scientific english

References / citation rules

• Use an EndNote-compatible citation style (recommended: numbered/Vancouver)
• Use only peer-reviewed research articles
• Do not use books
• Avoid non-primary sources
• Cite evidence for all non-general claims (especially mechanisms)

Content flow (in this order) (Start right away there is no need for abstract)

Part 1: circRNAs (general)

• What circRNAs are and how they differ from linear RNAs
• Biogenesis: back-splicing (key steps and major regulators)
• Key properties: stability, localization (nuclear vs cytoplasmic), abundance
• Cellular mechanisms (evidence-based)
• Interaction with RNA-binding proteins (binding/sequestration/scaffolding)
• Regulation of transcription/splicing (where shown)
• miRNA-related regulation (only if supported by functional validation; avoid overclaiming sponging)
• Translation (only where experimentally demonstrated)

Part 2: circRNAs in salivary glands (exocrine organs)

• Evidence for circRNA expression and roles in salivary gland tissues/cell types (acinar/ductal, others if studied)
• Findings from saliva or extracellular vesicles/exosomes (only if supported by research articles)
• Evidence related to development or differentiation (if available)
• circRNAs in salivary gland-related conditions (research-article evidence)
• Inflammation/autoimmune contexts/Tumors (benign/malignant; mechanistic findings where available) (e.g., Sjgrens, sialadenitis)
• There is a research gap regarding their circRNA role in salivary gland (only talk about this is the research is limited)

Writing expectations

• Keep it narrative with smooth transitions (not a list of studies)
• Clearly separate demonstrated mechanisms from associations
• Use cautious wording when evidence is indirect (suggests, associated with)

I will need plagiarism and AI detection report using turnitin.